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KMID : 0380420130370040177
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Journal of Prventive Veterinary Medicine
2013 Volume.37 No. 4 p.177 ~ p.180
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Efficacy of two virulence gene-deleted Salmonella
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Lee John-Hwa
Choi Yeong-Hwan
Choi Min-Su
Hur Jin
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Abstract
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We previously developed a novel attenuated Salmonella Typhimurium (S.Typhimurium) △lon△cpxR vaccine. This study was conducted in order to examine whether this vaccine could effectively protect growing piglets against Salmonella infection. Pregnant sows in group A were primed and boosted with the vaccine, whereas pregnant sows in group B received sterile PBS-sucrose. After farrowing, newborn piglets in groups A and B were challenged with a wild type virulent S. Typhimurium at three weeks of age. During the study, serum IgG titers of piglets in group A were significantly higher than those of piglets in group B (P<0.001). In addition, clinical signs were observed in 5.9% of piglets in group A during the entire experimental period after the challenge, while diarrhea was observed in 81.6% of piglets in group B. These results indicate that vaccination of the pregnant sows resulted in effective protection in piglets against Salmonella infection.
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KEYWORD
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Salmonellosis, suckling piglet, live attenuated vaccine, protection
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